COMET stands for Comparison of Operative to Monitoring and Endocrine Therapy for low-risk ductal carcinoma in situ (DCIS). This study will look at different management strategies for DCIS. It is the first national study in the United States (US) to do so. A randomized clinical trial will enroll 1200 women with low-risk DCIS. Enrollment will take place at about 100 cancer centers throughout the US. The study is funded by the Patient-Centered Outcomes Research Institute (PCORI).


The COMET study will look at two different interventions for DCIS:

  1. Standard care. This may include surgery (lumpectomy or mastectomy). It may also include radiation therapy.
  2. Active surveillance. This includes mammograms and physical exams every six months. Surgery is only recommended if needed.

In either group, you and your doctor will decide whether endocrine therapy is a good option.

Principal Investigator(s) 

Kristi Harrington, MD, PhD

Clinical Trial Categories



Tina Fortney, RN BSN, CCRC: 425.688.5407, Tina.Fortney@overlakehospital.org

Hania Shakalia, CRC, 424.635.6082, Hania.Shakalia@overlakehospital.org

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