Skip to main content

Quick menu

  • (425) 688-5000
  • MyChart
  • Giving
Home

Main menu

  • Doctors
  • Locations
  • Services
  • Visit
    • Classes & Events
    • Health Library
    • Healthy Outlook
    • Medical Records
    • View All
  • About
    • Careers
    • Contact
    • Giving
    • Project FutureCare
    • Volunteer
    • View All
  • Giving
  • Careers
    • Employee Benefits
    • Working Here
    • View All
Overlake Medical Center

Quick menu - Mobile

  • (425) 688-5000
  • MyChart
  • Giving

Main menu - Mobile

  • Doctors
  • Locations
  • Services
  • Visit
    • Classes & Events
    • Health Library
    • Healthy Outlook
    • Medical Records
    • View All
  • About
    • Careers
    • Contact
    • Giving
    • Project FutureCare
    • Volunteer
    • View All
  • Giving
  • Careers
    • Employee Benefits
    • Working Here
    • View All

COMET

Breadcrumb

  1. Home
  2. About
  3. Clinical Trials
  4. Studies

Share

Copy Link

Comparison of Operative to Monitoring and Endocrine Therapy (COMET) trial for low risk DCIS: A phase III prospective randomized trial.

Objective

Ductal carcinoma in situ (DCIS) is considered the earliest detectable form of pre-breast cancer. Almost all women with DCIS experience no symptoms. Cancerous cells are present in DCIS but they are trapped within certain areas of the breast called ducts. DCIS is therefore not considered an invasive cancer and most cases will not progress to invasive disease. Despite this low risk for progression, current standards for treating DCIS include surgery such as mastectomy, radiation and hormonal therapy. In this trial a participant with low-risk DCIS will be randomly chosen to either receive the standard treatment or be randomly chosen to undergo active monitoring instead. Active monitoring requires no surgery or radiation but instead requires more frequent mammograms and doctor visits to closely monitor whether the disease is progressing or not. If evidence during this monitoring suggests that the cancer is spreading, then standard treatment with surgery and radiation may be reconsidered. The goal of this study is to better understand whether close monitoring of DCIS is adequate in managing the disease rather than treating it with the more invasive treatments currently used.

Sponsor

  • Alliance Foundation Trials, LLC.

Principal Investigator

  • Kristi Harrington, MD, PhD

Sponsors

  • University of Washington
  • Fred Hutchinson Cancer Research Center

Contact

  • Email the Clinical Research team

Resources

  • DCIS Options.
  • ClinicalTrials.gov: Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial For Low Risk DCIS (COMET).

Studies

  • Breast Tissue Repository
  • COMET
  • CREST-2
  • CREST-H
  • Convalescent Plasma Expanded Access
  • EXACT
  • LiquiBand FIX8
  • MiRNA
  • Remdesivir Expanded Access
  • SALLY
  • SATURN
  • SEER-Lung
  • SEERPRO
Subscribe to Healthy Outlook

Your privacy is important to us. Submission of this form is subject to our online privacy policy.

Overlake Medical Center & Clinics

1035 116th Ave NE, Bellevue, WA 98004

Phone: (425) 688-5000

Overlake Medical Center & Clinics
Overlake Medical Center & Clinics
Overlake Medical Center & Clinics
Overlake Medical Center & Clinics
Overlake Medical Center & Clinics

Footer Sitemap

  • CONTRIBUTE
    • Foundation
    • Make a Gift
    • Volunteer
  • JOIN OUR TEAM
    • Careers
  • PROFESSIONALS
    • For Employees
    • For Providers
    • For Volunteers
  • PATIENT RESOURCES
    • Billing & Insurance
    • Campus Map & Parking
    • Financial Assistance
    • Pay Your Bill
    • Schedule an Appointment
  • CONNECT
    • Contact Us
    • Classes & Events
    • Community Benefit
    • Healthy Outlook
    • Newsroom

Footer Sitemap

  • CONTRIBUTE
    • Foundation
    • Make a Gift
    • Volunteer
  • JOIN OUR TEAM
    • Careers
  • PROFESSIONALS
    • For Employees
    • For Providers
    • For Volunteers
  • PATIENT RESOURCES
    • Billing & Insurance
    • Campus Map & Parking
    • Financial Assistance
    • Pay Your Bill
    • Schedule an Appointment
  • CONNECT
    • Contact Us
    • Classes & Events
    • Community Benefit
    • Healthy Outlook
    • Newsroom

© 2021 Overlake Hospital Medical Center. All rights reserved.

Footer

  • Online Privacy Notice
  • Policies and Notices
  • Nondiscrimination Policy
  • Language Assistance Policy